THE EFFICACY AND SAFETY OF SARILUMAB, FULLY HUMAN MONOCLONAL ANTIBODIES AGAINST INTERLEUKIN 6 RECEPTOR, IN RHEUMATOID ARTHRITIS: NEW EVIDENCE

The efficacy and safety of sarilumab, fully human monoclonal antibodies against interleukin 6 receptor, in rheumatoid arthritis: new evidence

Rheumatoid arthritis (RA) is an immune-mediated inflammatory (autoimmune) rheumatic disease of unknown etiology, which Circulation Hose is characterized by chronic erosive arthritis (synovitis) and systemic damage of internal organs and leads to early disability and shorter life expectancy in patients.Much attention is paid to studying the role of

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Analysis of substructural variation in families of enzymatic proteins with applications to protein function prediction

Abstract Background Structural variations caused by a wide range of physico-chemical and biological sources directly influence the function of a protein.For enzymatic proteins, the structure and chemistry of the catalytic binding site residues can be loosely defined as a substructure of the protein.Comparative analysis of drug-receptor substructure

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